Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.

Yap, V.A. and Loong, B.J. and Ting, K.N. and Loh, S.H.S. and Yong, K.T. and Low, Y.Y. and Kam, T.S. and Lim, K.H. (2015) Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn. Phytochemistry, 109. pp. 96-102. ISSN 0031-9422

Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.phytochem.2014.10.032

Abstract

Hispidacine, an 8,4′-oxyneolignan featuring incorporation of an unusual 2-hydroxyethylamine moiety at C-7, and hispiloscine, a phenanthroindolizidine alkaloid, were isolated from the stem-bark and leaves of the Malaysian Ficus hispida Linn. Their structures were established by spectroscopic analysis. Hispidacine induced a moderate vasorelaxant activity in rat isolated aorta, while hispiloscine showed appreciable antiproliferative activities against MDA-MB-231, MCF-7, A549, HCT-116 and MRC-5 cell lines.

Item Type: Article
Uncontrolled Keywords: Ficus hispida; Moraceae; Alkaloids; Neolignans; Phenanthroindolizidine; NMR; Antiproliferation; Vasorelaxation
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QH Natural history
R Medicine
Divisions: Faculty of Science > Dept of Chemistry
Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Sep 2018 03:04
Last Modified: 25 Sep 2018 03:04
URI: http://eprints.um.edu.my/id/eprint/19394

Actions (login required)

View Item View Item