Yap, V.A. and Loong, B.J. and Ting, K.N. and Loh, S.H.S. and Yong, Kien Thai and Low, Yun Yee and Kam, Toh Seok and Lim, K.H. (2015) Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn. Phytochemistry, 109. pp. 96-102. ISSN 0031-9422, DOI https://doi.org/10.1016/j.phytochem.2014.10.032.
Full text not available from this repository.Abstract
Hispidacine, an 8,4′-oxyneolignan featuring incorporation of an unusual 2-hydroxyethylamine moiety at C-7, and hispiloscine, a phenanthroindolizidine alkaloid, were isolated from the stem-bark and leaves of the Malaysian Ficus hispida Linn. Their structures were established by spectroscopic analysis. Hispidacine induced a moderate vasorelaxant activity in rat isolated aorta, while hispiloscine showed appreciable antiproliferative activities against MDA-MB-231, MCF-7, A549, HCT-116 and MRC-5 cell lines.
| Item Type: | Article |
|---|---|
| Funders: | MOHE Malaysia (FRGS/2/2013/SG01/UNIM/02/1 and HIR-005) |
| Uncontrolled Keywords: | Ficus hispida; Moraceae; Alkaloids; Neolignans; Phenanthroindolizidine; NMR; Antiproliferation; Vasorelaxation |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QH Natural history R Medicine |
| Divisions: | Faculty of Science > Department of Chemistry Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 25 Sep 2018 03:04 |
| Last Modified: | 22 Mar 2021 03:36 |
| URI: | http://eprints.um.edu.my/id/eprint/19394 |
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