Lim, A.; Amini, A.; D'Orsogna, L.J.; Rajasuriar, R.; Kramski, M.; Lewin, S.R.; Purcell, D.F.; Price, P.; French, M.A. (2011) Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection. AIDS, 25 (11). ISSN 0269-9370Full text not available from this repository.
OBJECTIVES: To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection. DESIGN: Cross-sectional study in antiretroviral therapy (ART)-naive (n = 23) and ART-treated (n = 27) HIV patients. METHODS: Antibodies to LPS and immunoglobulins, assayed in stored serum, and matched memory B-cell counts were correlated with levels of LPS and bacterial 16S ribosome DNA (16S rDNA), assayed in stored plasma. RESULTS: In ART-naive patients, plasma LPS levels correlated inversely with serum levels of IgG and IgA antibodies to LPS (P = 0.03 and 0.006, respectively), serum levels of IgA anti-LPS correlated with total IgA (P < 0.0001) and levels of IgG anti-LPS correlated with IgM memory B-cell counts (P = 0.025). In ART-treated patients, plasma LPS levels were not related to levels of LPS antibodies, but were related to CD4 T-cell and switched memory B-cell counts. There were no correlations with plasma levels of 16S rDNA. CONCLUSION: Plasma LPS levels were associated with antibody and possibly B-cell responses to LPS in ART-naive HIV patients, whereas they were associated with the degree of immune reconstitution in ART-treated patients.
|Journal or Publication Title:||AIDS|
|Divisions:||Faculty of Medicine|
|Depositing User:||Mr. Faizal Hamzah|
|Date Deposited:||04 Aug 2011 11:27|
|Last Modified:||15 Nov 2013 11:04|
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