Lim, A. and Amini, A. and D'Orsogna, L.J. and Rajasuriar, R. and Kramski, M. and Lewin, S.R. and Purcell, D.F. and Price, P. and French, M.A. (2011) Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection. AIDS, 25 (11). ISSN 0269-9370, DOI 21572302.
Full text not available from this repository.Abstract
OBJECTIVES: To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection. DESIGN: Cross-sectional study in antiretroviral therapy (ART)-naive (n = 23) and ART-treated (n = 27) HIV patients. METHODS: Antibodies to LPS and immunoglobulins, assayed in stored serum, and matched memory B-cell counts were correlated with levels of LPS and bacterial 16S ribosome DNA (16S rDNA), assayed in stored plasma. RESULTS: In ART-naive patients, plasma LPS levels correlated inversely with serum levels of IgG and IgA antibodies to LPS (P = 0.03 and 0.006, respectively), serum levels of IgA anti-LPS correlated with total IgA (P < 0.0001) and levels of IgG anti-LPS correlated with IgM memory B-cell counts (P = 0.025). In ART-treated patients, plasma LPS levels were not related to levels of LPS antibodies, but were related to CD4 T-cell and switched memory B-cell counts. There were no correlations with plasma levels of 16S rDNA. CONCLUSION: Plasma LPS levels were associated with antibody and possibly B-cell responses to LPS in ART-naive HIV patients, whereas they were associated with the degree of immune reconstitution in ART-treated patients.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | HIV |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Mr. Faizal Hamzah |
| Date Deposited: | 04 Aug 2011 03:27 |
| Last Modified: | 15 Nov 2013 03:04 |
| URI: | http://eprints.um.edu.my/id/eprint/1930 |
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