Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis

Haerian , M.S.; Haerian , B.S. (2011) Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis. European Journal of Gastroenterology and Hepatology. ISSN 08159319

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Abstract

Objective: Recent genome-wide association studies of colorectal cancer (CRC) have identified rs6983267 G>T and rs10505477 T>C polymorphisms as key loci in the 8q24 region to be associated with CRC. In the present study, we performed a meta-analysis to determine whether these loci are risk factors for susceptibility to CRC. Materials and Methods: We meta-analyzed the 22 included studies (47,003 cases and 45,754 controls) that evaluated the role of rs6983267 G>T and rs10505477 T>C polymorphisms with CRC risk under alternative genetic models. Results: Meta-analysis of the pooled data showed allelic and genotypic association of the rs6983267 polymorphism with CRC risk in the Asian, European, and Americans with European ancestry. Sub-analysis of the American studies showed negative results in the studies with non-identified ethnicity of the subjects. Meta-analysis of included studies of rs10505477 polymorphism identified allelic and genotypic association with CRC risk in the American subjects. Further meta-analysis of the American studies demonstrated positive results in the studies with non-identified ethnicity of the samples. Conclusion: Our data suggested that the rs6983267 G>T polymorphism is a risk factor for CRC in the Asians, European, and American with the European ancestry populations.

Item Type: Article
Creators:
  1. Haerian , M.S.(Shaheed Beheshti University)
  2. Haerian , B.S.(University of Malaya)
Journal or Publication Title: European Journal of Gastroenterology and Hepatology
Uncontrolled Keywords: Pharmacology
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 03 Aug 2011 10:16
Last Modified: 03 Aug 2011 10:16
URI: http://eprints.um.edu.my/id/eprint/1916

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