Ethnic variation of genetic (idiopathic) generalized epilepsy in Malaysia

Lim, K.S. and Ng, C.C. and Chan, C.K. and Foo, W.S. and Low, J.S.Y. and Tan, C.T. (2017) Ethnic variation of genetic (idiopathic) generalized epilepsy in Malaysia. Seizure - European Journal of Epilepsy, 45. pp. 24-27. ISSN 1059-1311

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Official URL: http://dx.doi.org/10.1016/j.seizure.2016.11.011

Abstract

Purpose Ethnic variation in epilepsy classification was reported in the Epilepsy Phenome/Genome Project. This study aimed to determine the ethnic variation in the prevalence of genetic (idiopathic) generalized epilepsy (GGE) and GGE with family history in a multi-ethnic Asian population in Malaysia. Method In this cross-sectional study, 392 patients with a clinical diagnosis of GGE were recruited in the neurology outpatient clinic, University of Malaya Medical Centre (UMMC), from January 2011 till April 2016. Results In our epilepsy cohort (n = 2100), 18.7% were diagnosed to have GGE. Of those, 28.6% >(N = 112) had family history of epilepsy with a mean age of seizure onset of 16.5 years old, and 42.0% had myoclonic seizures (N = 47). The lifetime prevalence of epilepsy among first-degree relative of those with GGE and positive family history was 15.0%. Analysis according to ethnicity showed that Malaysian Chinese had the lowest percentage of GGE among those with epilepsy (12.3%), as compared with Indian and Malay (25.3% and 21.3%, p < 0.001). In addition, 32.1% of these Indian patients with GGE had positive family history, which is more than the Malay (26.4%) and Chinese (27.5%) ethnic groups. Consanguineous marriage was noted in 5 Indian families with positive family history (9.6%). Conclusion There was ethnic variation in the prevalence of GGE, whereby the Malaysian Chinese had the lowest percentage of GGE as compared with Indian and Malay. A substantial proportion of GGE had positive family history among the three ethnics groups.

Item Type: Article
Uncontrolled Keywords: Genetics; Epilepsy; Genetic generalized epilepsy; Idiopathic generalized epilepsy; Familial epilepsy
Subjects: Q Science > QH Natural history
R Medicine
Divisions: Faculty of Medicine
Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 05 Sep 2018 07:00
Last Modified: 05 Sep 2018 07:00
URI: http://eprints.um.edu.my/id/eprint/19117

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