Kong, B.H.; Hanifah, Y.A.; Yusof, M.Y.M.; Thong, K.L. (2011) Antimicrobial Susceptibility Profiling and Genomic Diversity of Multidrug-Resistant Acinetobacter baumannii Isolates from a Teaching Hospital in Malaysia. Japanese Journal of Infectious Diseases, 64 (4). pp. 337-40. ISSN 1344-6304Full text not available from this repository.
The resistance phenotypes and genomic diversity of 185 Acinetobacter baumannii isolates obtained from the intensive care unit (ICU) of a local teaching hospital in Kuala Lumpur from 2006 to 2009 were determined using antimicrobial susceptibility testing and pulsed-field gel electrophoresis (PFGE). Antibiogram analyses showed that the isolates were fully resistant to β-lactam antimicrobials and had high resistance rates to the other antimicrobial agents tested. However, the isolates were susceptible to polymyxin B. Resistance to cefoperazone/sulbactam was only detected in strains isolated from 2007 to 2009. Some environmental isolates and an isolate from the hands of a healthcare worker (HCW) had identical resistance profiles and PFGE profiles that were closely related to patient isolates. Cluster analyses based on the PFGE profiles showed there was a persistent clone of endemic isolates in the ICU environment. The transmission route from HCWs to fomites to patients, which caused a long-term infection in the ICU of the University Malaya Medical Centre, was observed in this study. These data provide a better understanding of A. baumannii epidemiology within the hospital and the possible transmission routes. Knowledge of changes in the resistance rates of A. baumannii in our local hospital will improve antimicrobial therapy.
|Journal or Publication Title:||Japanese Journal of Infectious Diseases|
|Additional Information:||Microbiology Division, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia|
|Divisions:||Faculty of Science > Institute of Biological Sciences|
|Depositing User:||Mr. Faizal Hamzah|
|Date Deposited:||01 Aug 2011 11:59|
|Last Modified:||15 Dec 2014 14:21|
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