Antibacterial properties of poly (octanediol citrate)/gallium-containing bioglass composite scaffolds

Zeimaran, E. and Pourshahrestani, S. and Djordjevic, I. and Pingguan-Murphy, B. and Kadri, N.A. and Wren, A.W. and Towler, M.R. (2016) Antibacterial properties of poly (octanediol citrate)/gallium-containing bioglass composite scaffolds. Journal of Materials Science: Materials in Medicine, 27 (1). pp. 1-11. ISSN 0957-4530

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Official URL: https://doi.org/10.1007/s10856-015-5620-2

Abstract

Bioactive glasses may function as antimicrobial delivery systems through the incorporation and subsequent release of therapeutic ions. The aim of this study was to evaluate the antimicrobial properties of a series of composite scaffolds composed of poly(octanediol citrate) with increased loads of a bioactive glass that releases zinc (Zn2+) and gallium (Ga3+) ions in a controlled manner. The antibacterial activity of these scaffolds was investigated against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The ability of the scaffolds to release ions and the subsequent ingress of these ions into hard tissue was evaluated using a bovine bone model. Scaffolds containing bioactive glass exhibited antibacterial activity and this increased in vitro with higher bioactive glass loads; viable cells decreased to about 20 % for the composite scaffold containing 30 % bioactive glass. The Ga3+ release rate increased as a function of time and Zn2+ was shown to incorporate into the surrounding bone.

Item Type: Article
Uncontrolled Keywords: Antibacterial Activity; Simulated Body Fluid; Bioactive Glass; Ga2O3; Composite Scaffold
Subjects: R Medicine
T Technology > TJ Mechanical engineering and machinery
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 15 May 2018 06:15
Last Modified: 15 May 2018 06:15
URI: http://eprints.um.edu.my/id/eprint/18677

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