Zeimaran, E. and Pourshahrestani, S. and Djordjevic, I. and Pingguan-Murphy, Belinda and Kadri, Nahrizul Adib and Wren, A.W. and Towler, M.R. (2016) Antibacterial properties of poly (octanediol citrate)/gallium-containing bioglass composite scaffolds. Journal of Materials Science: Materials in Medicine, 27 (1). pp. 1-11. ISSN 0957-4530, DOI https://doi.org/10.1007/s10856-015-5620-2.
Full text not available from this repository.Abstract
Bioactive glasses may function as antimicrobial delivery systems through the incorporation and subsequent release of therapeutic ions. The aim of this study was to evaluate the antimicrobial properties of a series of composite scaffolds composed of poly(octanediol citrate) with increased loads of a bioactive glass that releases zinc (Zn2+) and gallium (Ga3+) ions in a controlled manner. The antibacterial activity of these scaffolds was investigated against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The ability of the scaffolds to release ions and the subsequent ingress of these ions into hard tissue was evaluated using a bovine bone model. Scaffolds containing bioactive glass exhibited antibacterial activity and this increased in vitro with higher bioactive glass loads; viable cells decreased to about 20 % for the composite scaffold containing 30 % bioactive glass. The Ga3+ release rate increased as a function of time and Zn2+ was shown to incorporate into the surrounding bone.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education Malaysia: High Impact Research Grant (UM.C/625/1/HIR/MOHE/ENG/58), University of Malaya Research Grant (UMRG, RG156-12AET) |
| Uncontrolled Keywords: | Antibacterial Activity; Simulated Body Fluid; Bioactive Glass; Ga2O3; Composite Scaffold |
| Subjects: | R Medicine T Technology > TJ Mechanical engineering and machinery |
| Divisions: | Faculty of Engineering |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 May 2018 06:15 |
| Last Modified: | 10 Feb 2020 08:40 |
| URI: | http://eprints.um.edu.my/id/eprint/18677 |
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