InterRNA: A database of base interactions in RNA structures

Appasamy, S.D. and Hamdani, H.Y. and Ramlan, E.I. and Firdaus-Raih, M. (2016) InterRNA: A database of base interactions in RNA structures. Nucleic Acids Research, 44 (D1). D266-D271. ISSN 0305-1048

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Official URL: https://doi.org/10.1093/nar/gkv1186

Abstract

A major component of RNA structure stabilization are the hydrogen bonded interactions between the base residues. The importance and biological relevance for large clusters of base interactions can be much more easily investigated when their occurrences have been systematically detected, catalogued and compared. In this paper, we describe the database InterRNA (INTERactions in RNA structures database-http://mfrlab.org/interrna/) that contains records of known RNA 3D motifs as well as records for clusters of bases that are interconnected by hydrogen bonds. The contents of the database were compiled from RNA structural annotations carried out by the NASSAM (http://mfrlab.org/grafss/nassam) and COGNAC (http://mfrlab.org/grafss/cognac) computer programs. An analysis of the database content and comparisons with the existing corpus of knowledge regarding RNA 3D motifs clearly show that InterRNA is able to provide an extension of the annotations for known motifs as well as able to provide novel interactions for further investigations.

Item Type: Article
Uncontrolled Keywords: Databases, Nucleic Acid; Hydrogen Bonding; Molecular Sequence Annotation; Nucleic Acid Conformation; RNA
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Divisions: Faculty of Computer Science & Information Technology
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 21 Nov 2017 02:42
Last Modified: 21 Nov 2017 02:42
URI: http://eprints.um.edu.my/id/eprint/18329

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