Modified poly(caprolactone trifumarate) with embedded gelatin microparticles as a functional scaffold for bone tissue engineering

Al-Namnam, N.M.N. and Kim, K.H. and Chai, W.L. and Ha, K.O. and Siar, Chong Huat and Ngeow, Wei Cheong (2016) Modified poly(caprolactone trifumarate) with embedded gelatin microparticles as a functional scaffold for bone tissue engineering. Journal of Applied Polymer Science, 133 (30). p. 43711. ISSN 0021-8995

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Official URL: https://doi.org/10.1002/app.43711

Abstract

Bone tissue engineering offers high hopes in reconstructing bone defects that result from trauma, infection, tumors, and other conditions. However, there remains a need for novel scaffold materials that can effectively stimulate ossification with appropriate functional properties. Therefore, a novel injectable, biodegradable, and biocompatible scaffold made by incorporating modified poly(caprolactone trifumarate) (PCLTF) with embedded gelatin microparticles (GMPs) as porogen is developed. Specifically, in vitro and in vivo tests were carried out. For the latter, to determine the osteogenic ability of PCLTF-GMPs scaffolds, and to characterize bone-formation, these scaffolds were implanted into critical-sized defects of New Zealand white rabbit craniums. Field Emission Scanning Electron Microscope (FESEM) demonstrated cells of varying shapes attached to the scaffold surface in vitro. The PCLTF-GMPs demonstrated improved biocompatibility in vivo. Polyfluorochrome tracers detected bone growth occurring in the PCLTF-GMPs filled defects. By incorporating PCLTF with GMPs, we have fabricated a promising self-crosslinkable biocompatible and osteoconducive scaffold for bone tissue engineering.

Item Type: Article
Uncontrolled Keywords: Applications; Biocompatibility; Biomaterials; Biomedical applications; Polyesters
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: Faculty of Dentistry
Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 14 Nov 2017 04:01
Last Modified: 18 Mar 2019 02:07
URI: http://eprints.um.edu.my/id/eprint/18254

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