Enhanced expression of endothelial nitric oxide synthase in the myocardium ameliorates the progression of left ventricular hypertrophy in L-arginine treated wistar-kyoto rats

Ahmad, A. and Sattar, M.A. and Rathore, H.A. and Abdulla, M.H. and Khan, S.A. and Abdullah, N.A. and Johns, E.J. (2016) Enhanced expression of endothelial nitric oxide synthase in the myocardium ameliorates the progression of left ventricular hypertrophy in L-arginine treated wistar-kyoto rats. Journal of Physiology and Pharmacology, 67 (1). pp. 31-44. ISSN 0867-5910

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Official URL: http://www.jpp.krakow.pl/journal/archive/02_16/art...

Abstract

The present study investigated the roleof endothelial nitric oxide synthase (eNOS) enzyme in the development of left ventricular hypertrophy (LVH) in Wistar-Kyoto rats. The effect of L-arginine administration on cardiac structure, arterial stiffness, renal and systemic hemodynamic parameters was studied and the change in expression of eNOS and cystathione g lyase (CSE) in the myocardium of LVH rats was evaluated. LVH was induced using isoprenaline (5 mg/kg, S.C.) and caffeine (62 mg/L in drinking water) for 14 days. Following to that, L-arginine (1.25g/L in drinking water) was given for 5 weeks as a donor of NO. eNOS and CSE gene expressions were down regulated in the LVH group by about 35% and 67% respectively when compared to control. However, in the LVH group treated with L-arginine there was up regulation of eNOS by almost 27% and down regulation in CSE by 24% when compared to control (all P < 0.05). Heart index and H2S plasma levels were reduced by almost 53% in the L-arginine treated LVH group compared to the control (all P < 0.05). Mean arterial pressure, heart rate and pulse wave velocity were reduced while renal blood perfusion increased in L-arginine treated LVH rats compared to their untreated counterparts (all P < 0.05). The enhanced expression of eNOS in L-arginine treated LVH rats resulted in the amelioration of oxidative and haemodynamic parameters suggesting that NO system is an important therapeutic target in cardiac and LV hypertrophies.

Item Type: Article
Uncontrolled Keywords: L-arginine; Left ventricular hypertrophy; Endothelial nitric oxide synthase; Pulse wave velocity
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 24 Oct 2017 05:13
Last Modified: 24 Oct 2017 05:13
URI: http://eprints.um.edu.my/id/eprint/18091

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