Risperidone and Olanzapne in-patient Utilization in the University of Malaya Medical Centre, Kuala Lumpur

Hatm, A.; Yen, T.H. (2006) Risperidone and Olanzapne in-patient Utilization in the University of Malaya Medical Centre, Kuala Lumpur. Journal of the University of Malaya Medical Centre (JUMMEC), 9 (1). pp. 23-29. ISSN 1823-7339

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Abstract

The objective of this study was to compare in-patient drug use patterns, costs, and outcomes associated with risperidone or olanzapine in a naturalistic clinical setting. Retrospective chart reviews of 92 patients with psychotic disorders were conducted at the University of Malaya Medical Centre (UMMC). Data was collected from patients who were hospitalized and for whom risperidone or olanzapine was the drug of first choice for long-term pharmacologic treatment. Proportion of patients for whom efficacy of the studied treatment could be established (as rated by the treating physician) was higher, but not significantly, with risperidone compared to olanzapine (p = 0.46). The average dose of the studied medication was 2.9 ± 1.0 mg/day for risperidone and 9.7 ± 2.4 mg/day for olanzapine. The total cost was significantly higher (p <0.0001) for olanzapine (RM140.40; 95% CI: 108.4–181.9)compared to risperidone (RM50.80, 95% CI: 39.5–65.3). The daily cost was also significantly higher for olanzapine (RM19.16; 95% CI: 17.72–20.72) compared to risperidone RM4.95; 95% CI: 4.46–5.51, p < 0.0001). Analysis of responders showed significantly higher daily and total costs of treatment with olanzapine compared to risperidone. These preliminary data suggest that treatment with risperidone may be more costeffective than treatment with olanzapine. However, a longer duration of study and more data is needed before a proper conclusion on cost-effectiveness is made.

Item Type: Article
Creators:
  1. Hatm, A.
  2. Yen, T.H.
Journal or Publication Title: Journal of the University of Malaya Medical Centre (JUMMEC)
Additional Information: This study was supported by a grant from Janssen Cilag, a division of Johnson & Johnson Sdn. Bhd. The authors would like to thank Dr. Subash Kumar and Dr.Andrew Mohanraj for their assistance in collecting data.
Uncontrolled Keywords: Antipsychotic; Outcome; In-patience,
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 22 Jul 2011 10:14
Last Modified: 22 Jul 2011 10:14
URI: http://eprints.um.edu.my/id/eprint/1805

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