Chondrogenic potential of physically treated bovine cartilage matrix derived porous scaffolds on human dermal fibroblast cells

Moradi, A. and Ataollahi, F. and Sayar, K. and Pramanik, S. and Chong, P.P. and Khalil, A.A. and Kamarul, Tunku and Pingguan-Murphy, Belinda (2015) Chondrogenic potential of physically treated bovine cartilage matrix derived porous scaffolds on human dermal fibroblast cells. Journal of Biomedical Materials Research Part A, 104 (1). pp. 245-256. ISSN 1549-3296

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Official URL: http://dx.doi.org/10.1002/jbm.a.35561

Abstract

Extracellular matrices have drawn attention in tissue engineering as potential biomaterials for scaffold fabrication because of their bioactive components. Noninvasive techniques of scaffold fabrication and cross-linking treatments are believed to maintain the integrity of bioactive molecules while providing proper architectural and mechanical properties. Cartilage matrix derived scaffolds are designed to support the maintenance of chondrocytes and provide proper signals for differentiation of chondroinducible cells. Chondroinductive potential of bovine articular cartilage matrix derived porous scaffolds on human dermal fibroblasts and the effect of scaffold shrinkage on chondrogenesis were investigated. An increase in sulfated glycosaminoglycans production along with upregulation of chondrogenic genes confirmed that physically treated cartilage matrix derived scaffolds have chondrogenic potential on human dermal fibroblasts.

Item Type: Article
Uncontrolled Keywords: Cartilage matrix; Chondrogenic; Human dermal fibroblast; Scaffold; Shrinkage
Subjects: R Medicine
Divisions: Faculty of Engineering
Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 05 Oct 2017 07:51
Last Modified: 10 Oct 2018 09:07
URI: http://eprints.um.edu.my/id/eprint/17900

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