Hepatoprotective Effects of Chinese Medicine Herbs Decoction on Liver Cirrhosis in Rats

Mat-Rahim, N.A. and Lim, T.-H. and Nor-Amdan, N.A. and AbuBakar, Sazaly (2017) Hepatoprotective Effects of Chinese Medicine Herbs Decoction on Liver Cirrhosis in Rats. Evidence-Based Complementary and Alternative Medicine, 2017. pp. 1-7. ISSN 1741-427X

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Official URL: http://dx.doi.org/10.1155/2017/6125829

Abstract

Hepatoprotective and curative activities of aqueous extract of decoction containing 10 Chinese medicinal herbs (HPE-XA-08) were evaluated in Sprague–Dawley albino rats with liver damage induced by thioacetamide (TAA). These activities were assessed by investigating the liver enzymes level and also histopathology investigation. Increases in alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels were observed in rats with cirrhotic liver. No significant alterations of the liver enzymes were observed following treatment with HPE-XA-08. Histopathology examination of rats treated with HPE-XA-08 at 250 mg/kg body weight, however, exhibited moderate liver protective effects. Reduced extracellular matrix (ECM) proteins within the hepatocytes were noted in comparison to the cirrhotic liver. The curative effects of HPE-XA-08 were observed with marked decrease in the level of ALP (more than 3x) and level of GGT (more than 2x) in cirrhotic rat treated with 600 mg/kg body weight HPE-XA-08 in comparison to cirrhotic rat treated with just water diluent. Reversion of cirrhotic liver to normal liver condition in rats treated with HPE-XA-08 was observed. Results from the present study suggest that HPE-XA-08 treatment assisted in the protection from liver cirrhosis and improved the recovery of cirrhotic liver.

Item Type: Article
Uncontrolled Keywords: Hepatoprotective Effects; Chinese Medicine Herbs; Decoction; Liver Cirrhosis; Rats
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 10 Jul 2017 04:45
Last Modified: 13 Feb 2019 08:16
URI: http://eprints.um.edu.my/id/eprint/17467

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