Pathogenicity of Porphyromonas asaccharolytica in Adult Periodontitis of Malaysian Samples

Himratul-Aznita, W.H. and Mahmood, A.A. (2008) Pathogenicity of Porphyromonas asaccharolytica in Adult Periodontitis of Malaysian Samples. Current Research in Bacteriology, 1 (1). pp. 23-27. ISSN 1994-5426

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Official URL: http://scialert.net/abstract/?doi=crb.2008.23.27

Abstract

Bacterial toxin of Porphyromonas asaccharolytica strains obtained from adult periodontitis were analysed using mouse model. Results from subcutaneous injection with whole bacterial cells of 108 and 1010 cells mL-1 failed to induce any infection. However when bacterial concentration of 1012 cells mL-1 was used, all P. asaccharolytica strains were able to induced the development of localized lesion on balb/c mice. In addition, infected mice appeared cachectic with ruffled hair. Thus, infection with the latter concentration was pathogenic and was dose dependent. The toxin was also found to be heat labile for all strains. Therefore, we conclude that the extracellularly toxin produced by P. asaccharolytica of our local isolates which were obtained from adult periodontitis, is virulent and heat labile.

Item Type: Article
Uncontrolled Keywords: Pathogenicity; Porphyromonas asaccharolytica; Adult Periodontitis; Malaysian Samples
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 30 May 2017 13:37
Last Modified: 30 May 2017 13:37
URI: http://eprints.um.edu.my/id/eprint/17397

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