Lau, W.K. and Goh, B.H. and Kadir, H.A. and Shu-Chien, A.C. and Muhammad, T.S.T. (2015) Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells. Molecules, 20 (12). pp. 22301-22314. ISSN 1420-3049,
Full text not available from this repository.Abstract
Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPAR ligand activity. They were corresponded to PPAR-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPAR. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Swietenia macrophylla; PPAR gamma ligand; GLUT4 translocation; Glucose uptake |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Depositing User: | Mrs. Siti Mawarni Salim |
| Date Deposited: | 08 Sep 2016 02:42 |
| Last Modified: | 08 Sep 2016 02:42 |
| URI: | http://eprints.um.edu.my/id/eprint/16383 |
Actions (login required)
 |
View Item |
