Effects of silicate and carbonate substitution on the properties of hydroxyapatite prepared by aqueous co-precipitation method

Bang, L.T. and Ramesh, S. and Purbolaksono, J. and Ching, Y.C. and Long, B.D. and Chandran, H. and Ramesh, S. and Othman, R. (2015) Effects of silicate and carbonate substitution on the properties of hydroxyapatite prepared by aqueous co-precipitation method. Materials & Design, 87. pp. 788-796. ISSN 0261-3069

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Official URL: DOI: 10.1016/j.matdes.2015.08.069

Abstract

This research was conducted to investigate the effects of silicate and carbonate substitutions in hydroxyapatite (HA) on phase retention, physical properties, and in vitro biological response. A wet chemical method was employed to synthesize silicate-substituted HA (Si-HA) and carbonate-substituted HA (CHA). It was shown that the presence of silicate and carbonate ions in the HA lattice increases the specific surface area and Ca/P molar ratio. In addition, the substitution also resulted in a reduction in the crystallinity of the HA powder and promoted better bioactivity of the sintered body. This was confirmed through in vitro cell culture experiment which revealed that the osteoblast cells adhered well on the surface of the ceramic and that ionic-substituted HA exhibited better cell performance than the control HA. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Hydroxyapatite; Ionic-substituted hydroxyapatite; Characterization; In vitro evaluation; Cell response
Subjects: Q Science > Q Science (General)
Depositing User: Mrs. Siti Mawarni Salim
Date Deposited: 04 Aug 2016 04:49
Last Modified: 04 Aug 2016 04:49
URI: http://eprints.um.edu.my/id/eprint/16175

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