Combination of drugs acting on the natriuretic system and the renin-angiotensin system in heart failure.

Chee, K.H.; Amudha, K.; Hussain, N.A.; Haizal, H.K.; Choy, Anna-Maria J.; Lang, C.C. (2003) Combination of drugs acting on the natriuretic system and the renin-angiotensin system in heart failure. Journal of the renin-angiotensin-aldosterone system : JRAAS, 4 (3). pp. 140-8. ISSN 1470-3203

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Abstract

Conventional diuretic agents are very effective agents in relieving volume overload and congestive symptoms in chronic heart failure (CHF). However, they are associated with activation of the renin-angiotensin system (RAS) and the sympathetic nervous system and a reduction in glomerular filtration rate, all of which have been associated with adverse outcomes in CHF. Therefore, there is an increasing interest in drugs that target the natriuretic system without neurohormonal activation and deterioration of renal function. In this review, we will discuss the underlying rationale and evidence behind currently pursued strategies that target the natriuretic system. This includes the administration of natriuretic peptides (NPs) and strategies that potentiate the NP system, such as neutral endopeptidase inhibition. We will also highlight some potentially important interactions of these strategies with drugs that target the RAS.

Item Type: Article
Creators:
  1. Chee, K.H.
  2. Amudha, K.
  3. Hussain, N.A.
  4. Haizal, H.K.
  5. Choy, Anna-Maria J.
  6. Lang, C.C.
Journal or Publication Title: Journal of the renin-angiotensin-aldosterone system : JRAAS
Additional Information: Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Uncontrolled Keywords: Drug Therapy, Combination; Heart Failure/drug therapy; Humans
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 14 Jun 2011 12:11
Last Modified: 21 Dec 2014 16:57
URI: http://eprints.um.edu.my/id/eprint/1582

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