Ethnicity and drug therapy for hypertension.

Amudha, K.; Wong, Li P.; Choy, Anna-Maria J.; Lang, Chim C. (2003) Ethnicity and drug therapy for hypertension. Current pharmaceutical design, 9 (21). pp. 1691-701. ISSN 1381-6128

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Abstract

Physiological and pharmacological responses may be influenced by ethnicity as a result of genetic factors, environmental factors and/or their interaction. This review is divided into 2 parts. Firstly, there will be overview of ethnicity as a determinant of drug metabolism and response with reference to antihypertensive agents. The concept of ethnicity has been applied extensively to the study of hypertension especially in American blacks in whom the hypertension is more common and more aggressive. Thus, the second part of this review will then focus on examining the black-white differences in physiological responses to pharmacological challenge that may provide a link between these models and known ethnic differences in drug responses. We will discuss the hypertension studies that have examined the relative effectiveness of different classes of antihypertensive agents including several recent cardiovascular outcome trials that either have a high proportion of blacks or were conducted entirely in black subjects.

Item Type: Article
Journal or Publication Title: Current pharmaceutical design
Additional Information: Department of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Uncontrolled Keywords: Antihypertensive Agents/metabolism; Antihypertensive Agents/pharmacology; Antihypertensive Agents/therapeutic use
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 14 Jun 2011 12:07
Last Modified: 20 Oct 2014 16:16
URI: http://eprints.um.edu.my/id/eprint/1578

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