Criofolinine and vernavosine, new pentacyclic indole alkaloids incorporating pyrroloazepine and pyridopyrimidine moieties derived from a common yohimbine precursor

Nge, C.E. and Gan, C.Y. and Lim, K.H. and Ting, KN. and Low, Y.Y. and Kam, T.S. (2014) Criofolinine and vernavosine, new pentacyclic indole alkaloids incorporating pyrroloazepine and pyridopyrimidine moieties derived from a common yohimbine precursor. Organic Letters, 16 (24). pp. 6330-6333.

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Abstract

Two new indole alkaloids characterized by previously unencountered natural product skeletons, viz., criofolinine (1), incorporating a pyrroloazepine motif within a pentacyclic ring system, and vernavosine (2, isolated as its ethyl ether derivative 3, which on hydrolysis regenerated the putative precursor alkaloid 2), incorporating a pyridopyrimidine moiety embedded within a pentacyclic carbon framework, were isolated from a Malayan Tabernaemontana species. The structures and absolute configuration of these alkaloids were determined on the basis of NMR and MS analysis and confirmed by X-ray diffraction analysis.

Item Type: Article
Funders: UNSPECIFIED
Subjects: R Medicine
Depositing User: MR Faizal II H
Date Deposited: 29 Dec 2015 02:03
Last Modified: 29 Dec 2015 02:03
URI: http://eprints.um.edu.my/id/eprint/15390

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