Nge, C.E. and Gan, C.Y. and Lim, K.H. and Ting, KN. and Low, Y.Y. and Kam, T.S. (2014) Criofolinine and vernavosine, new pentacyclic indole alkaloids incorporating pyrroloazepine and pyridopyrimidine moieties derived from a common yohimbine precursor. Organic Letters, 16 (24). pp. 6330-6333.
Full text not available from this repository.Abstract
Two new indole alkaloids characterized by previously unencountered natural product skeletons, viz., criofolinine (1), incorporating a pyrroloazepine motif within a pentacyclic ring system, and vernavosine (2, isolated as its ethyl ether derivative 3, which on hydrolysis regenerated the putative precursor alkaloid 2), incorporating a pyridopyrimidine moiety embedded within a pentacyclic carbon framework, were isolated from a Malayan Tabernaemontana species. The structures and absolute configuration of these alkaloids were determined on the basis of NMR and MS analysis and confirmed by X-ray diffraction analysis.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Subjects: | R Medicine |
| Depositing User: | Dr Mohd Faizal Hamzah |
| Date Deposited: | 29 Dec 2015 02:03 |
| Last Modified: | 29 Dec 2015 02:03 |
| URI: | http://eprints.um.edu.my/id/eprint/15390 |
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