Chemopreventive properties of phytosterols and maslinic acid extracted from coleus tuberosus in inhibiting the expression of EBV early-antigen in raji cells

Mooi, L.Y. and Wahab, N.A. and Lajis, N. and Ali, A.M. (2010) Chemopreventive properties of phytosterols and maslinic acid extracted from coleus tuberosus in inhibiting the expression of EBV early-antigen in raji cells. Chemistry & Biodiversity, 7 (5). pp. 1267-1275. ISSN 1612-1872

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Abstract

Bioassay-guided fractionation of a MeOH extract of tubers of Coleus tuberosus afforded the active anti-tumor-promoting compounds identified as the triterpenoid 2 alpha,3 beta-dihydroxyolean-12-en-28-oic acid (maslinic acid; CT2) and a phytosterol mixture (CT1). CT1 consists of stigmasterol (32%), beta-sitosterol (40.3%), and campesterol (27.7%) as determined by capillary gas chromatography. CT1 and CT2 showed very strong anti-tumor-promoting activities at IC(50) 0.7 mu g/ml and 0.1 mu g/ml, respectively, in a convenient, short-term in vitro assay, i.e., the inhibition of Epstein Barr virus (EBV) activation induced by phorbol 12-myristate 13-acetate (PMA) and sodium butyrate. We report for the first time the anti-tumor-promoting activity of 2 alpha,3 beta-dihydroxyolean-12-en-28-oic acid and show that a mixture of stigmasterol, beta-sitosterol, and campesterol is more potent than the individual components in inhibiting tumor-promoting activity.

Item Type: Article
Additional Information: 3rd Summit on System Biology 2009 - The Microbial World and Beyond, Richmond, VA, JUN 16-19, 2009
Subjects: Q Science > Q Science (General)
Depositing User: MR Faizal II H
Date Deposited: 28 Dec 2015 12:50
Last Modified: 28 Dec 2015 12:50
URI: http://eprints.um.edu.my/id/eprint/15358

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