Mooi, L.Y. and Wahab, N.A. and Lajis, N. and Ali, A.M. (2010) Chemopreventive properties of phytosterols and maslinic acid extracted from coleus tuberosus in inhibiting the expression of EBV early-antigen in raji cells. Chemistry & Biodiversity, 7 (5). pp. 1267-1275. ISSN 1612-1872,
Full text not available from this repository.Abstract
Bioassay-guided fractionation of a MeOH extract of tubers of Coleus tuberosus afforded the active anti-tumor-promoting compounds identified as the triterpenoid 2 alpha,3 beta-dihydroxyolean-12-en-28-oic acid (maslinic acid; CT2) and a phytosterol mixture (CT1). CT1 consists of stigmasterol (32%), beta-sitosterol (40.3%), and campesterol (27.7%) as determined by capillary gas chromatography. CT1 and CT2 showed very strong anti-tumor-promoting activities at IC(50) 0.7 mu g/ml and 0.1 mu g/ml, respectively, in a convenient, short-term in vitro assay, i.e., the inhibition of Epstein Barr virus (EBV) activation induced by phorbol 12-myristate 13-acetate (PMA) and sodium butyrate. We report for the first time the anti-tumor-promoting activity of 2 alpha,3 beta-dihydroxyolean-12-en-28-oic acid and show that a mixture of stigmasterol, beta-sitosterol, and campesterol is more potent than the individual components in inhibiting tumor-promoting activity.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | 3rd Summit on System Biology 2009 - The Microbial World and Beyond, Richmond, VA, JUN 16-19, 2009 |
| Subjects: | Q Science > Q Science (General) |
| Depositing User: | Dr Mohd Faizal Hamzah |
| Date Deposited: | 28 Dec 2015 12:50 |
| Last Modified: | 28 Dec 2015 12:50 |
| URI: | http://eprints.um.edu.my/id/eprint/15358 |
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