Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children

Lum, L.C.S. and Borja-Tabora, C.F. and Breiman, R.F. and Vesikari, T. and Sablan, B.P. and Chay, O.M. and Tantracheewathorn, T. and Schmitt, H.J. and Lau, Y.L. and Bowonkiratikachorn, P. and Tam, J.S. and Lee, B.W. and Tan, K.K. and Pejcz, J. and Cha, S. and Gutierrez-Brito, M. and Kaltenis, P. and Vertruyen, A. and Czajka, H. and Bojarskas, J. and Brooks, W.A. and Cheng, S.M. and Rappaport, R. and Baker, S. and Gruber, W.C. and Forrest, B.D. (2010) Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children. Vaccine, 28 (6). pp. 1566-1574.

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Abstract

Children aged 11 to <24 months received 2 intranasal doses of live attenuated influenza vaccine (LAIV) or placebo, 35 +/- 7 days apart. Dose 1 was administered concomitantly with a combined measles, mumps, and rubella vaccine (Priorix). Seroresponses to measles and mumps were similar between groups. Compared with placebo, response rates to rubella in LAIV+Priorix recipients were statistically lower at a 15IU/mL threshold (83.9% vs 78.0%) and the prespecified noninferiority criteria were not met. In a post hoc analysis using an alternate widely accepted threshold of 10IU/mL, the noninferiority criteria were met (93.4% vs 89.8%). Concomitant administration with Priorix did not affect the overall influenza protection rate of LAIV (78.4% and 63.8% against antigenically similar influenza strains and any strain, respectively). (C) 2009 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Combined vaccines; Live attenuated influenza vaccine; Measles-mumps-rubella vaccine; Vaccine interference
Subjects: R Medicine
Depositing User: MR Faizal II H
Date Deposited: 22 Dec 2015 02:01
Last Modified: 22 Dec 2015 02:01
URI: http://eprints.um.edu.my/id/eprint/15194

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