Growth hormone deficiency and cardiovascular risk.

Hew, F.L. and O'Neal, D. and Kamarudin, N. and Alford, F.P. and Best, J.D. (1998) Growth hormone deficiency and cardiovascular risk. Baillière's Clinical Endocrinology and Metabolism, 12 (2). pp. 199-216. ISSN 0950-351X

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It is now recognized that growth hormone (GH) deficiency in adults represents a distinct clinical syndrome that encompasses reduced psychological well-being as well as specific metabolic abnormalities. The latter features, which include hypertension, central obesity, insulin resistance, dyslipidaemia and coagulopathy, closely resemble those of metabolic insulin resistance syndrome. The increased cardiovascular morbidity and mortality demonstrated in these GH-deficient (GHD) adults reinforce the close association between the two syndromes. Replacement of GH in GHD adults has resulted in a marked reduction of central obesity and significant reduction in total cholesterol but little change in other risk factors, in particular insulin resistance and dyslipidaemia. The persistent insulin resistance and dyslipidaemia, together with the elevation of plasma insulin levels and lipoprotein (a) with GH replacement in these subjects are of concern. Long-term follow-up data are required to assess the impact of GH replacement on the cardiovascular morbidity and mortality of GHD adults. Further exploration of the appropriateness of the GH dosage regimens currently being employed is also indicated.

Item Type: Article
Additional Information: Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Uncontrolled Keywords: Blood Coagulation Factors/metabolism; Blood Coagulation Factors/physiology
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 09 Jun 2011 02:49
Last Modified: 13 Mar 2013 08:42

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