Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla

Lim, Siew-Huah and Tan, Shin-Jowl and Low, Yun-Yee and Kam, Toh-Seok (2010) Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla. Journal of Natural Products, 74 (12). pp. 2556-2562.

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Abstract

Four new linearly fused bisindole alkaloids, lumutinines A D (1-4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline-macroline-type bisindoles, while lumutinines C (3) and D (4) were constituted from the union of macroline and sarpagine moieties. A reinvestigation of the stereochemical assignment of alstoumerine (8) by NMR and X-ray diffraction analyses indicated that the configuration at C-16 and C-19 required revision.

Item Type: Article
Funders: UNSPECIFIED
Subjects: Q Science > Q Science (General)
Depositing User: Dr Mohd Faizal Hamzah
Date Deposited: 09 Nov 2015 01:31
Last Modified: 09 Nov 2015 01:31
URI: http://eprints.um.edu.my/id/eprint/14691

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