Epstein-Barr virus associated diseases: an update

Pathmanathan, R. (1993) Epstein-Barr virus associated diseases: an update. The Malaysian Journal of Pathology, 15 (2). pp. 105-13. ISSN 0126-8635

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Abstract

The Epstein-Barr virus (EBV), traditionally linked etiologically with infectious mononucleosis (IM), endemic Burkitt lymphoma (BL) and nasopharyngeal carcinoma (NPC) has in recent years been associated with a host of other conditions. Viral strategies for entry into cells and persistence, as well as various molecular mechanisms involved in latency, replication and transformation have been elucidated. EBV termini analysis has demonstrated the essentially clonal nature of BL, NPC and preneoplastic lesions of the nasopharynx. Strain variation between isolates of EBV suggests that differences in epithelial cell tropism among strains may exist. Treatment of EBV-associated syndromes is largely supportive although antivirals may play a role in the management of oral hairy leukoplakia. At the present time, the development of an effective vaccine remains a viable proposition.

Item Type: Article
Additional Information: Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur
Uncontrolled Keywords: Burkitt Lymphoma/microbiology; Herpesviridae Infections/drug therapy
Subjects: R Medicine > RB Pathology > Theories of disease. Etiology. Pathogenesis
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 01 Jun 2011 04:24
Last Modified: 26 Oct 2018 01:53
URI: http://eprints.um.edu.my/id/eprint/1437

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