Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells

Aziz, J. and Abu Kassim, N.L. and Abu Kasim, N.H. and Haque, N. and Rahman, M.R. (2015) Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells. BMC Complementary and Alternative Medicine, 15 (215). ISSN 1472-6882

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Official URL: http://www.biomedcentral.com/1472-6882/15/215

Abstract

Background: Use of Carica papaya leaf extracts, reported to improve thrombocyte counts in dengue patients, demands further analysis on the underlying mechanism of its thrombopoietic cytokines induction. Methods: In vitro cultures of peripheral blood leukocytes (PBL) and stem cells from human exfoliated deciduous teeth (SHED) were treated with unripe papaya pulp juice (UPJ) to evaluate its potential to induce thrombopoietic cytokines (IL-6 and SCF). Results: In vitro scratch gap closure was significantly faster (p < .05) in SHED culture treated with UPJ. IL-6 concentration was significantly increased (p < .05) in SHED and PBL culture supernatant when treated with UPJ. SCF synthesis in SHED culture was also significantly increased (p < .05) when treated with UPJ. Conclusion: In vitro upregulated synthesis of IL-6 and SCF both in PBL and SHED reveals the potential mechanism of unripe papaya to induce thrombopoietic cytokines synthesis in cells of hematopoietic and mesenchymal origin.

Item Type: Article
Uncontrolled Keywords: Dengue fever; Megakaryopoiesis; Thrombocytes; Interleukin-6; Stem cell Factor
Subjects: R Medicine > RK Dentistry
Depositing User: Mr Ahmad Azwan Azman
Date Deposited: 22 Sep 2015 01:09
Last Modified: 22 Sep 2015 01:09
URI: http://eprints.um.edu.my/id/eprint/14035

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