Rahim, M.A.A. and Rahim, Z.H.A. and Ahmad, W.A.W. and Hashim, Onn Haji (2015) Can saliva proteins be used to predict the onset of acute Myocardial infarction among high-risk patients? International Journal of Medical Sciences, 12 (4). pp. 329-335. ISSN 1449-1907, DOI https://doi.org/10.7150/ijms.11280.
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Abstract
Human saliva plays a pivotal role in digesting food and maintaining oral hygiene. The presence of electrolytes, mucus, glycoproteins, enzymes, antibacterial compounds, and gingival crevicular fluid in saliva ensures the optimum condition of oral cavity and general health condition. Saliva collection has been proven non-invasive, convenient, and inexpensive compared to conventional venipuncture procedure. These distinctive advantages provide a promising potential of saliva as a diagnostic fluid. Through comprehensive analysis, an array of salivary proteins and peptides may be beneficial as biomarkers in oral and systemic diseases. In this review, we discuss the utility of human salivary proteomes and tabulate the recent salivary biomarkers found in subjects with acute myocardial infarction as well as respective methods employed. In a clinical setting, since acute myocardial infarction contributes to large cases of mortality worldwide, an early intervention using these biomarkers will provide an effective solution to reduce global heart attack incidence particularly among its high-risk group of type-2 diabetes mellitus patients. The utility of salivary biomarkers will make the prediction of this cardiac event possible due to its reliability hence improve the quality of life of the patients. Current challenges in saliva collection are also addressed to improve the quality of saliva samples and produce robust biomarkers for future use in clinical applications.
| Item Type: | Article |
|---|---|
| Funders: | PPPC Grant, University of Malaya : PG110-2014A |
| Uncontrolled Keywords: | Saliva; biomarker; acute myocardial infarction; proteomics; type-2 diabetes mellitus |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Dept of Oral Biology |
| Depositing User: | Mr Ahmad Azwan Azman |
| Date Deposited: | 03 Jul 2015 01:37 |
| Last Modified: | 24 Oct 2019 08:31 |
| URI: | http://eprints.um.edu.my/id/eprint/13672 |
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