MicroRNAs: Association with radioresistant and potential uses of natural remedies as green gene therapeutic approaches

Jothy, S.L. and Chen, Y. and Vijayarathna, S. and Kanwar, J.R. and Sasidharan, S. (2015) MicroRNAs: Association with radioresistant and potential uses of natural remedies as green gene therapeutic approaches. Current Gene Therapy, 15 (1). pp. 15-20. ISSN 1566-5232,

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Abstract

Radiotherapy plays an essential primary role in cancer patients. Regardless of its significant advances in treatment options, tumor recurrence and radio-resistance in cancer cells still occur in a high percentage of patients. Furthermore, the over expression of miRNAs accompanies the development of radio-resistant cancer cells. Consequently, miRNAs might serve as therapeutic targets for the treatment of radio-resistance in cancer cells. The findings of the current research also signify that the use of a natural anti-miRNA substance could inhibit specific miRNAs, and, concurrently, these natural remedies could exhibit radioprotective activity against the healthy cells during radiotherapy. Therefore, in this review, we have reported the association of miRNAs with radio-resistance and the potential uses of natural remedies as green gene therapeutic approaches, as well as radioprotectors against the adverse effects of irradiation on healthy cells during radiotherapy.

Item Type:	Article
Funders:	UNSPECIFIED
Subjects:	R Medicine > RK Dentistry
Divisions:	Faculty of Dentistry
Depositing User:	Mr Ahmad Azwan Azman
Date Deposited:	16 Jun 2015 06:20
Last Modified:	16 Jun 2015 06:20
URI:	http://eprints.um.edu.my/id/eprint/13570

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