The epstein-Barr virus and the pathogenesis of lymphoma

Vockerodt, M. and Yap, L.F. and Shannon-Lowe, C. and Curley, H. and Wei, W.B. and Vrzalikova, K. and Murray, P.G. (2015) The epstein-Barr virus and the pathogenesis of lymphoma. The Journal of Pathology. ISSN 0022-3417, DOI https://doi.org/10.1002/path.4459.

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Abstract

Since the discovery in 1964 of the Epstein-Barr virus (EBV) in African Burkitt lymphoma, this virus has been associated with a remarkably diverse range of cancer types. Because EBV persists in the B cells of the asymptomatic host, it can easily be envisaged how it contributes to the development of B-cell lymphomas. However, EBV is also found in other cancers, including T-cell/natural killer cell lymphomas and several epithelial malignancies. Explaining the aetiological role of EBV is challenging, partly because the virus probably contributes differently to each tumour and partly because the available disease models cannot adequately recapitulate the subtle variations in the virus-host balance that exist between the different EBV-associated cancers. A further challenge is to identify the co-factors involved; because most persistently infected individuals will never develop an EBV-associated cancer, the virus cannot be working alone. This article will review what is known about the contribution of EBV to lymphoma development. Copyright (c) 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Item Type:	Article
Funders:	UNSPECIFIED
Uncontrolled Keywords:	Burkitt lymphoma; Epstein-Barr virus; Hodgkin lymphoma; diffuse large B-cell lymphoma
Subjects:	R Medicine > RK Dentistry
Divisions:	Faculty of Dentistry
Depositing User:	Mr Ahmad Azwan Azman
Date Deposited:	11 Jun 2015 03:41
Last Modified:	30 Dec 2015 04:27
URI:	http://eprints.um.edu.my/id/eprint/13556

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