Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity

Hirasawa, Y. and Hara, M. and Nugroho, A.E. and Sugai, M. and Zaima, K. and Kawahara, N. and Goda, Y. and Awang, K. and Hadi, A.H.A. and Litaudon, M. and Morita, H. (2010) Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity. The Journal of Organic Chemistry, 75 (12). pp. 4218-4223.

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Abstract

Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown to be in an atropisomeric relationship. Bisnicalaterines B and C (1 and 2) showed potent vasorelaxant activity on isolated rat aorta.

Item Type: Article
Funders: UNSPECIFIED
Subjects: R Medicine
Depositing User: Mr Faizal 2
Date Deposited: 07 Apr 2015 08:45
Last Modified: 07 Apr 2015 08:45
URI: http://eprints.um.edu.my/id/eprint/13222

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