Wong, W.F. and Kohu, K. and Chiba, T. and Sato, T. and Satake, M. (2011) Interplay of transcription factors in T-cell differentiation and function: the role of Runx. Immunology, 132 (2). pp. 157-164. ISSN 0019-2805, DOI https://doi.org/10.1111/j.1365-2567.2010.03381.x.
Full text not available from this repository.Abstract
Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes’ entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interplay with these master regulators in various aspects of T cells’ immunity. In this review article, we first explain roles of Th-Pok and Runx3 in differentiation of CD4 versus CD8 single positive cells, and later focus on cross-regulation of Th-Pok and Runx3 and their relationship with other factors such as TCR strength. Next, we provide evidences for the direct interplay of Runx1/3 with T-bet and GATA3 during Th1 versus Th2 commitment to activate or silence transcription of signature cytokine genes, IFNγ and IL4. Lastly, we explain feed-forward relationship between Runx1 and Foxp3 and discuss roles of Runx1 in regulatory T cells’ suppressive activity. This review highlights an essential importance of Runx molecules in controlling various T cell subsets’ differentiation and functions through molecular interplay with the master transcription factors in terms of protein-protein interaction as well as regulation of gene expression.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Cell differentiation; Gene expression; Gene targeting; T lymphocytes; Transcription factor |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Mar 2015 01:41 |
| Last Modified: | 13 Mar 2015 01:41 |
| URI: | http://eprints.um.edu.my/id/eprint/13025 |
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