2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans

Lim, C.S.Y. and Wong, W.F. and Rosli, R. and Ng, K.P. and Seow, H.F. and Chong, P.P. (2009) 2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans. Journal of Basic Microbiology, 49 (6). pp. 579-583. ISSN 0233-111X

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/jobm.20...

Abstract

Candida albicans is capable of undergoing yeast-hypha transition to attain pathogenicity in humans. In this study, we investigated the differential expression of CaSIR2 via quantitative real-time PCR (qPCR), during yeast-hypha transition with and without the presence of 2-dodecanol. SIR2 transcript levels were found to be significantly enhanced after hyphal induction as compared to the yeast form. This study found that 2-dodecanol is able to inhibit hyphal development and block SIR2 up-regulation, even in hyphal-inducing growth conditions. We suggest that SIR2 may be involved in Candida albicans quorum-sensing and serum-induced yeast-hyphae transition via the Ras1-cAMP-Efg1 signalling cascade.

Item Type: Article
Uncontrolled Keywords: Candida albicans; SIR2 gene; Quantitative real-time PCR; Gene expression; Dodecanol
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 13 Mar 2015 01:14
Last Modified: 13 Mar 2015 01:14
URI: http://eprints.um.edu.my/id/eprint/13022

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