Lim, C.S.Y. and Wong, W.F. and Rosli, R. and Ng, K.P. and Seow, H.F. and Chong, P.P. (2009) 2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans. Journal of Basic Microbiology, 49 (6). pp. 579-583. ISSN 0233-111X, DOI https://doi.org/10.1002/jobm.200900035.
Full text not available from this repository.Abstract
Candida albicans is capable of undergoing yeast-hypha transition to attain pathogenicity in humans. In this study, we investigated the differential expression of CaSIR2 via quantitative real-time PCR (qPCR), during yeast-hypha transition with and without the presence of 2-dodecanol. SIR2 transcript levels were found to be significantly enhanced after hyphal induction as compared to the yeast form. This study found that 2-dodecanol is able to inhibit hyphal development and block SIR2 up-regulation, even in hyphal-inducing growth conditions. We suggest that SIR2 may be involved in Candida albicans quorum-sensing and serum-induced yeast-hyphae transition via the Ras1-cAMP-Efg1 signalling cascade.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Candida albicans; SIR2 gene; Quantitative real-time PCR; Gene expression; Dodecanol |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Mar 2015 01:14 |
| Last Modified: | 13 Mar 2015 01:14 |
| URI: | http://eprints.um.edu.my/id/eprint/13022 |
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