Kohu, K. and Ohmori, H. and Wong, W.F. and Onda, D. and Wakoh, T. and Kon, S. and Yamashita, M. and Nakayama, T. and Kubo, M. and Satake, M. (2009) The Runx3 Transcription Factor Augments Th1 and Down-Modulates Th2 Phenotypes by Interacting with and Attenuating GATA3. Journal of Immunology, 183 (12). pp. 7817-7824. ISSN 0022-1767, DOI https://doi.org/10.4049/jimmunol.0802527.
Full text not available from this repository.Abstract
Recently, it was reported that the expression of Runt-related transcription factor 3 (Runx3) is up-regulated in CD4+ helper T cells during Th1 cell differentiation, and that Runx3 functions in a positive feed-forward manner with the T-box family transcription factor, T-bet, which is a master regulator of Th1 cell differentiation. The relative expression levels of IFN-γ and IL-4 are also regulated by the Th2-associated transcription factor, GATA3. Here, we demonstrate that Runx3 was induced in Th2 as well as Th1 cells and that Runx3 interacted with GATA3 and attenuated GATA3 transcriptional activity. Ectopic expression of Runx3 in vitro in cultured cells or transgenic expression of Runx3 in mice accelerated CD4+ cells to a Th1-biased population or down-modulated Th2 responses, in part by neutralizing GATA3. Our results suggest that the balance of Runx3 and GATA3 is one factor that influences the manifestation of CD4+ cells as the Th1 or Th2 phenotypes.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Runx3 Transcription Factor; Augments Th1; Down-Modulates Th2 Phenotypes; Attenuating GATA3 |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 13 Mar 2015 01:02 |
| Last Modified: | 13 Mar 2015 01:02 |
| URI: | http://eprints.um.edu.my/id/eprint/13021 |
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