Susceptible and protective HLA class 1 alleles against dengue fever and dengue hemorrhagic fever patients in a Malaysian population.

Appanna, R.; Ponnampalavanar, S.; Lum Chai See, L.; Sekaran, S.D. (2010) Susceptible and protective HLA class 1 alleles against dengue fever and dengue hemorrhagic fever patients in a Malaysian population. PloS one, 5 (9). ISSN 1932-6203

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Abstract

These are the first findings on genetic polymorphisms in our population and we conclude that: (1) In our total population, HLA-B*53 probably involve in disease susceptibility, while the HLA-A*03 and HLA-B*18 may confer protection from progression to severe disease; (2) In the Malay population, HLA-B*13 and B*18 are probably associated in disease susceptibility and protection, respectively. These results could furnish as a valuable predictive tool to identify ethnically different individuals at risk and/or protection from severe forms of DENV infection and would provide valuable informations for the design of future dengue vaccine.

Item Type: Article
Creators:
  1. Appanna, R.
  2. Ponnampalavanar, S.
  3. Lum Chai See, L.
  4. Sekaran, S.D.
Journal or Publication Title: PloS one
Additional Information: Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
Uncontrolled Keywords: Alleles; Case-Control Studies; Dengue/epidemiology
Subjects: R Medicine
Divisions: Faculty of Medicine > School of Biological Sciences
Depositing User: Mr. Faizal Hamzah
Date Deposited: 19 May 2011 11:13
Last Modified: 19 May 2011 11:13
URI: http://eprints.um.edu.my/id/eprint/1286

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