Appanna, R. and Ponnampalavanar, S. and Lum Chai See, L. and Sekaran, S.D. (2010) Susceptible and protective HLA class 1 alleles against dengue fever and dengue hemorrhagic fever patients in a Malaysian population. PLoS ONE, 5 (9). ISSN 1932-6203, DOI 20927388.
Full text not available from this repository.Abstract
These are the first findings on genetic polymorphisms in our population and we conclude that: (1) In our total population, HLA-B*53 probably involve in disease susceptibility, while the HLA-A*03 and HLA-B*18 may confer protection from progression to severe disease; (2) In the Malay population, HLA-B*13 and B*18 are probably associated in disease susceptibility and protection, respectively. These results could furnish as a valuable predictive tool to identify ethnically different individuals at risk and/or protection from severe forms of DENV infection and would provide valuable informations for the design of future dengue vaccine.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia |
| Uncontrolled Keywords: | Alleles; Case-Control Studies; Dengue/epidemiology |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine > School of Biological Sciences |
| Depositing User: | Mr. Faizal Hamzah |
| Date Deposited: | 19 May 2011 03:13 |
| Last Modified: | 04 Jul 2017 02:15 |
| URI: | http://eprints.um.edu.my/id/eprint/1286 |
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