Metallo-beta-lactamase-producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11

Khosravi, Y. and Tay, S.T. and Vadivelu, J. (2010) Metallo-beta-lactamase-producing imipenem-resistant Pseudomonas aeruginosa clinical isolates in a university teaching hospital in Malaysia: detection of IMP-7 and first identification of IMP-4, VIM-2, and VIM-11. Diagnostic Microbiology and Infectious Disease, 67 (3). pp. 294-296.

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Abstract

Ninety (n = 90) imipenem-resistant Pseudomonas aeruginosa (IRPA) clinical isolates collected randomly during 2005 to 2008 from University Malaya Medical Center were assessed for the presence of different variants of metallo-beta-lactamase (MBL) genes. Polymerase chain reaction (PCR) assay detected 32 (n = 32) MBL gene PCR-positive isolates with the presence of bla(IMP) gene in 14 (n = 14) and bla(VIM) in 18 (n = 18) isolates. Four allelic variants, bla(IMP-7) (12 isolates), bla(IMP-4) (2 isolates), bla(VIM-2) (17 isolates), and bla(VIM-11) (1 isolate), of MBL genes were identified. This study is the first report of detection of bla(IMP-4), bla(VIM-2), and bla(VIM-11) MBL genes from IRPA clinical isolates in Malaysia. (C) 2010 Elsevier Inc. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Metallo-beta-lactamase (MBL) genes; Pseudomonas aeruginosa; Imipenem resistance; bla(IMP); bla(VIM); Carbapenems
Subjects: R Medicine
Depositing User: Mr Faizal 2
Date Deposited: 12 Feb 2015 03:23
Last Modified: 12 Feb 2015 03:23
URI: http://eprints.um.edu.my/id/eprint/12746

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