Effects of Malaysian medicinal plants on macrophage functions in vitro study

Al-Bayaty, F.H. and Mohamed, M.A.A. and Abu Hassan, I. and Hussein, S.F. (2010) Effects of Malaysian medicinal plants on macrophage functions in vitro study. Journal of Medicinal Plants Research, 4 (14). pp. 1472-1476.

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Abstract

The effects of aqueous leaf extract of eight local medicinal plant species on the phagocytic and antibacterial potential of mouse peritoneal macrophages against Staphylococcus aureus were investigated. The mouse macrophages cultures were incubated with various concentrations (0.2, 0.4, 0.8, 1.6 and 3.2 mg/ml) of plant extracts in different sets of test tubes at 37 C for one hour. After incubation, their phagocytic and antibacterial effects on S. aureus were determined. Results have shown that the extracts of Orthosiphon stramineus, and Andrographis paniculata inhibited the phagocytic activity and intracellular killing of S. aureus compared with controls. Activated cells had more phagocytic activity and intracellular killing than normal macrophages. There were no differences in the viability of macrophage cells treated with extracts and those without extracts (control).

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: Aqueous plant extracts; murine macrophages; phagocytosis
Subjects: R Medicine
Depositing User: Mr Faizal 2
Date Deposited: 11 Feb 2015 06:34
Last Modified: 11 Feb 2015 06:34
URI: http://eprints.um.edu.my/id/eprint/12685

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