Qua, Choon-Seng and Manikam, J. and Goh, Khean Lee (2010) Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter pylori eradication regime in Asian patients: Is it still effective 10 years on? Chinese Journal of Digestive Diseases, 11 (4). pp. 244-248. ISSN 1443-9611,
Full text not available from this repository.Abstract
OBJECTIVE: To re-examine the efficacy and tolerability of 1-week proton pump inhibitor triple therapy as a first-line Helicobacter pylori (H. pylori) eradication therapy. METHODS: Consecutive participants with a positive rapid urease test during an outpatient upper endoscopy were included. All participants were given pantoprazole 40 mg b.i.d., amoxycillin 1 g b.i.d. and clarithromycin 500 mg b.i.d. for 1 week. They were asked to return after 1 week to report any side effects related to the medications and to check for compliance. Successful eradication was defined by negative 13C-urea breath test at least 4 weeks after the completion of therapy. RESULTS: A total of 191 patients were recruited into the study, of whom 81 were male (42.4%) and 110 female (57.6%), with a mean age of 55.6 (range 21-88) years. Overall 26 patients (13.6%) defaulted follow up and five patients were not compliant (taking less than 85%) with the medications. Per-protocol and intention-to-treat eradication rates were 84.4% (95% CI: 78.6-89.9%) and 71.2% (95% CI: 64.5-77.6%), respectively. Overall 68 participants (42.5%) reported no side effects, followed by 58 (36.3%) with a taste disturbance, 16 (10.0%) with epigastric pain, 15 (9.4%) with diarrhea, 13 (8.1%) with nausea or vomiting, 12 (7.5%) with loss of appetite, nine (5.6%) with dizziness and two (1.3%) with an allergic skin rash, none of which was severe. CONCLUSION: The current regime using pantoprazole, amoxycillin and clarithromycin is highly tolerable and effective and should continue to be recommended as a first-line therapy for H. pylori eradication in our setting.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | 13C-urea breath test; clarithromycin resistance; Helicobacter pylori eradication; triple therapy |
| Subjects: | R Medicine |
| Depositing User: | Mr Faizal 2 |
| Date Deposited: | 10 Feb 2015 07:42 |
| Last Modified: | 07 Feb 2019 09:24 |
| URI: | http://eprints.um.edu.my/id/eprint/12649 |
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