Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia

Ahmad, K. and Thomas, N.F. and Hadi, A.H.A. and Mukhtar, M.R. and Mohamad, K. and Nafiah, M.A. and Takeya, K. and Morita, H. and Litaudon, M. and Arai, H. and Awang, Khalijah (2010) Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia. Chemical & Pharmaceutical Bulletin, 58 (8). pp. 1085-1087.

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Abstract

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 21) NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.

Item Type: Article
Uncontrolled Keywords: Beta-carboline; indole; Neisosperma oppositifolia; Apocynaceae; vasorelaxant activity
Subjects: Q Science > Q Science (General)
Depositing User: Mr Faizal 2
Date Deposited: 09 Feb 2015 04:44
Last Modified: 01 Mar 2019 09:01
URI: http://eprints.um.edu.my/id/eprint/12608

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