Bilateral pallidal stimulation for X-linked dystonia parkinsonism

Wadia, Pettarusp M. and Lim, Shen-Yang and Lozano, Andres M. and Adams, John R. and Poon, Yu-Yan and Diaz, Cristina Torres and Moro, Elena (2010) Bilateral pallidal stimulation for X-linked dystonia parkinsonism. Archives of Neurology, 67 (8). pp. 1012-1017. ISSN 0003-9942, DOI https://doi.org/10.1001/archneurol.2010.187.

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Abstract

Objective: To report the clinical benefits of bilateral deep brain stimulation (DBS) of the globus pallidus internus (GPi) in a patient with X-linked dystonia parkinsonism (XDP). Design: Case report. Setting: Tertiary referral center. Patient: A 40-year-old Filipino man with genetically confirmed XDP and severely disabling generalized dystonia. Intervention: Bilateral GPi DBS. Main Outcome Measures: The primary outcome measures were the Burke-Fahn-Marsden Dystonia Scale (BFMDS) severity and disability scores, and the secondary outcome measure was the Unified Parkinson Disease Rating Scores. Results: At the 1-year postoperative follow-up, there was 80.4% improvement in the BFMDS severity score and 66.7% improvement in the BFMDS disability score. Conclusion: Bilateral GPi DBS seems to be very effective in improving dystonia in XDP.

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: Bilateral Pallidal Stimulation; X-Linked Dystonia Parkinsonism; Deep brain stimulation (DBS); Globus pallidus internus (GPi)
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr Faizal 2
Date Deposited: 09 Feb 2015 04:44
Last Modified: 24 Oct 2018 03:37
URI: http://eprints.um.edu.my/id/eprint/12605

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