Alias, Z. and Clark, A.G. (2010) Adult drosophila melanogaster glutathione S-transferases: effects of acute treatment with methyl parathion. Pesticide Biochemistry and Physiology, 98 (1). pp. 94-98.
Full text not available from this repository.Abstract
The effect of acute treatment of methyl parathion (MP) on the expression of BSP/GSH-agarose purified glutathione S-transferases (GSTs) in Drosophila melanogaster was investigated. Using 2-D gel analysis of the identified Epsilon-class, only DmGSTE6 (100%) and DmGSTE7 (72%) demonstrated significant increases in expression, suggesting the possibility that both may be involved in MP metabolism. A smaller percentage increase was also observed in DmGSTD1 (18%), a known DDT dehydrochlorinase, DmGSTE3 and DmGSTE9 and a putative Epsilon-class GST, CG16936, were shown not to be responsive to the challenge. Our finding demonstrates that not all member of the Epsilon-class GST, which are known for their role in insecticide resistance, are immediately responsive to this toxic challenge. (C) 2010 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Drosophila; Gluthathione S-transferases; Methyl parathion |
| Subjects: | R Medicine |
| Depositing User: | Mr Faizal 2 |
| Date Deposited: | 30 Jan 2015 03:06 |
| Last Modified: | 30 Jan 2015 03:06 |
| URI: | http://eprints.um.edu.my/id/eprint/12502 |
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