Acute oral toxicity of Pereskia bleo and Pereskia grandifolia in mice.

Sim, K S; Sri Nurestri, A M; Sinniah, S K; Kim, K H; Norhanom, A W (2010) Acute oral toxicity of Pereskia bleo and Pereskia grandifolia in mice. Pharmacognosy magazine, 6 (21). pp. 67-70. ISSN 0976-4062

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Abstract

Pereskia bleo and Pereskia grandifolia, belonging to the botanical family Cactaceae, have been traditionally used by the locals in Malaysia for treatment of various ailments. The current study reports the outcome of acute oral toxicity investigation of Pereskia bleo and Pereskia grandifolia, on ICR mice. No mortalities or evidence of adverse effects have been observed in ICR mice following acute oral administration at the highest dose of 2500 mg/ kg crude extracts of Pereskia bleo and Pereskia grandifolia. This is the first report on the acute oral toxicity of Pereskia bleo and Pereskia grandifolia and the findings of this study are in agreement with those of in vitro experiments and thus provide scientific validation on the use of the leaves of Pereskia bleo and Pereskia grandifolia.

Item Type: Article
Creators:
  1. Sim, K S
  2. Sri Nurestri, A M
  3. Sinniah, S K
  4. Kim, K H
  5. Norhanom, A W
Journal or Publication Title: Pharmacognosy magazine
Additional Information: Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Uncontrolled Keywords: Pereskia Bleo; Pereskia Grandifolia
Subjects: R Medicine
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Mr. Faizal Hamzah
Date Deposited: 17 May 2011 10:18
Last Modified: 17 May 2011 10:18
URI: http://eprints.um.edu.my/id/eprint/1241

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