Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua

Zhang, Hua-Wei and Zhang, J. and Hu, S. and Zhang, Zun-Jian and Zhu, Cheng-Jian and Ng, S.W. and Tan, Ren-Xiang (2010) Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua. Planta Medica, 76 (14). pp. 1616-1621.

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Abstract

Three new alkaloids, 15b-dehydro-5-N-acetylardeemin (3), 10-phenyl-[12]-cytochalasins Z16 (6) andZ17(7), were characterized from the liquid culture of the endophytic fungus Aspergillus terreus IFB-E030 along with six known derivatives, 5-N-acetylardeemin (1), 15b-beta-hydroxyl-5-N-acetylardeemin (2), cytochalasin E (4), rosellichalasin (5), cytochalasins Z11 (8), and Z13 (9). The structures of the new metabolites were established mainly by a combination of their 1D- and 2D-NMR spectra, single crystal X-ray diffraction, and the modified Mosher reaction. Biological assays indicated that cytochalasin Z17 (7) had moderate cytotoxicity against human nasopharyngeal epidermoid tumor KB cell line with an IC(50) value of 26.2 mu M.

Item Type: Article
Uncontrolled Keywords: Structure determination; natural products; Aspergillus terreus; ardeemin; cytochalasin
Subjects: Q Science > Q Science (General)
Depositing User: Mr Faizal 2
Date Deposited: 22 Jan 2015 02:02
Last Modified: 22 Jan 2015 02:02
URI: http://eprints.um.edu.my/id/eprint/12319

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