Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius

Deguchi, J. and Shoji, T. and Nugroho, A.E. and Hirasawa, Y. and Hosoya, T. and Shirota, O. and Awang, Khalijah and Hadi, A.H.A. and Morita, H. (2010) Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius. Journal of Natural Products-Copublished with the Am. Soc. of Pharmacognosy, 73 (10). pp. 1727-1729.

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Abstract

Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.

Item Type: Article
Funders: UNSPECIFIED
Subjects: Q Science > Q Science (General)
Depositing User: Mr Faizal 2
Date Deposited: 20 Jan 2015 03:02
Last Modified: 01 Mar 2019 08:51
URI: http://eprints.um.edu.my/id/eprint/12249

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