Rajasuriar, R. and Booth, D. and Solomon, A. and Chua, K. and Spelman, T. and Gouillou, M. and Schlub, T.E. and Davenport, M. and Crowe, S. and Elliott, J. and Hoy, J. and Fairley, C. and Stewart, G. and Cameron, P. and Lewin, S.R. (2010) Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: The role of interleukin 7 and interleukin 7 receptor alpha and microbial translocatioa. International Journal of Infectious Diseases, 202 (8). pp. 1254-1264.
Full text not available from this repository.Abstract
Background. Multiple host factors may influence CD4(+) T cell reconstitution in human immunodeficiency virus (HIV)-infected patients after suppressive antiretroviral therapy (ART). We hypothesized that residual immune activation and polymorphisms in the interleukin 7 (IL-7) receptor alpha (IL-7R alpha) gene were important for immune recovery. Methods. We examined HIV-infected patients receiving suppressive ART (n = 96) for their IL-7R alpha haplotypes and measured levels of lipopolysaccharide (LPS), soluble CD14, and IL-7 in plasma samples collected before and after ART initiation. Levels of soluble IL-7R alpha were measured in HIV-infected patients with IL-7R alpha haplotype 2 (n = 11) and those without IL-7R alpha haplotype 2 (n = 22). Multivariate analysis was used to identify variables associated with faster recovery to CD4(+) T cell counts of > 500 and > 200 cells/mu L. Results. Both LPS and soluble CD14 levels were significantly decreased with ART (P <.001, respectively) but remained elevated compared with uninfected controls. In a multivariate analysis, faster recovery to a CD4(+) T cell count of > 500 cells/mu L was significantly associated with higher baseline CD4(+) T cell count, younger age, lower pre-ART LPS level, higher pre-ART soluble CD14 level, lower pre-ART IL-7 level, and IL-7R alpha haplotype 2 (hazard ratio, 1.50; 95% confidence interval, 1.03-2.19; P = .034). HIV-infected patients with haplotype 2 had significantly lower soluble IL-7R alpha levels compared with those of patients without haplotype 2 (P <.001). Conclusion. Both the extent of immune depletion prior to ART and IL-7R alpha haplotype 2 are important determinants of time to CD4(+) T cell recovery to counts of > 500 cells/mu L.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Subjects: | Q Science > Q Science (General) |
| Depositing User: | Mr Faizal 2 |
| Date Deposited: | 19 Jan 2015 03:47 |
| Last Modified: | 19 Jan 2015 03:47 |
| URI: | http://eprints.um.edu.my/id/eprint/12170 |
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