Bee, P.C. and Gan, G.G. and Nadarajan, V.S. and Latiff, N.A. and Menaka, N. (2010) A man with concomitant polycythaemia vera and chronic myeloid leukemia: the dynamics of the two disorders. International Journal of Hematology, 91 (1). pp. 136-139. ISSN 0925-5710, DOI https://doi.org/10.1007/s12185-009-0471-6.
Full text not available from this repository.Abstract
The co-occurrence of JAK2 V617F mutation with BCR-ABL reciprocal translocation is uncommon. We report a 60-year-old man who initially presented with phenotype of polycythemia vera (PV), which evolved into chronic myeloid leukemia and back to PV once treatment with imatinib was commenced. JAK2 V617F mutation and BCR-ABL fusion transcripts were detected in the initial sample. However, JAK2 V617F alleles diminished when BCR-ABL mRNA burden increased and reappeared once the patient was commenced on imatinib. The dynamic interaction between JAK2 V617F and BCR-ABL implies that two independent clones exist with the JAK2 V617F clone only achieving clonal dominance when BCR-ABL positive clones are suppressed by imatinib.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Chronic myeloid leukemia; Polycythemia vera; Bcr-Abl; JAK2 V617F mutation; Stem cell |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Jan 2015 02:54 |
| Last Modified: | 14 Jan 2015 02:54 |
| URI: | http://eprints.um.edu.my/id/eprint/12023 |
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